Treatment of Chronic Lymphocytic Leukemia by Extracorporeal Irradiation
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چکیده
منابع مشابه
Treatment of chronic lymphocytic leukemia by extracorporeal irradiation.
T HE SENSITIVITY OF LYMPHOCYTES to irradiation provides a rationale for the use of extracorporeal irradiation (ECI ) of the circulating blood to destroy lymphocytes selectively. Since 1962, ECI has been used in various studies, including investigations of lymphocyte physiology and prolongation of allogeneic skin graft survival in calves. These studies1 established the basic feasibility and effe...
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cytes concerned,’4 and by the variety of behavior patterns displayednotably in regard to progression of the disease and response to therapy. This diversity is also reflected in the response shown by patients with CLL to treatment by extracorporeal irradiation of the blood ( ECIB). Patients so far treated by this technic at the Royal Marsden Hospital inelude nine with various forms of lymphoma. ...
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Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
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Major advances have occurred in our understanding of the biology, immunology, and opportunities for treatment of chronic lymphocytic leukemia (CLL) in recent times. Surface antigen analysis has helped us define classical CLL and differentiate it from variants such as marginal zone leukemia, mantle cell leukemia, and prolymphocytic leukemia. An important observation has been that the B-cells in ...
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ژورنال
عنوان ژورنال: Blood
سال: 1968
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v31.4.490.490